Vardenafilis an oral therapy used to treat erectile dysfunction and is sold under the trade names Levitra, Staxyn, and Vivanza. Vardenafil is a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscles in the corpus cavernosum and its associated arteries. During sexual arousal, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate in smooth muscle cells of the corpus cavernosum. cGMP, in turn, triggers smooth muscle relaxation, which increases blood flow to the penis, resulting in an erection. The tissue concentration of cGMP is regulated by the rate of both synthesis and degradation via phosphodiesterase (PDE). The most plentiful PDE in the human corpus cavernosum is cGMP specific phosphodiesterase type 5 (PDE5), and similarly, inhibition of PDE5 enhances erectile function by increasing the amount of cGMP.
How does Vardenafil treat?
Erectile Dysfunction is a multifaceted condition in men with many possible causes such as poor circulation, hormonal imbalance, nervous dysfunction, stress, anxiety, and depression. Vardenafil and other PDE5 inhibitors are often the first treatment for erectile dysfunction when physical causes are suspected.For example, it may be effective if poor circulation associated with diabetes or heart disease is causing your Erectile Dysfunction. PDE5 inhibitors are not an effective treatment for ED that is caused by psychological factors such as stress or anxiety. If psychological causes are suspected, your doctor may recommend psychotherapy.
Directions for use
Before using vardenafil, be sure to read the manufacturer's printed information leaflet on the inside of the pack. Reading this will give you more information about the pills as well as a full list of the side effects which you may experience from taking them.Take vardenafil exactly as your doctor has told you. It is intended for use only before sexual activity, not for continuous daily use. This pill should be taken 25-60 minutes before you plan to have sex, and it can be effective up to 4-5 hours after taking the pill. This tablet can be taken before or after a meal but if you have just had a meal that is high or high in fat, it may take a little longer to work.There are three strengths of vardenafil tablets: 5 mg, 10 mg, and 20 mg and you will likely be initially prescribed a 10 mg strength tablet by the doctor but may change it later based on your response. Take care not to consume more than one dose of vardenafil in any 24 hours.
How long does it take for Vardenafil to work?
Vardenafil is recommended to be taken before meals but should not be accompanied by high-fat meals as its effect is slightly delayed. It should be taken about 30 to 60 minutes before when you plan to have a relationship with your partner. The effect of this medicine lasts for 4 to 5 hours.
What are the Dosage instructions for Vardenafil?
Vardenafil tablets range from 2.5 to 20 mg and your doctor can help you figure out which dosage will be right for you. The starting dose of vardenafil for most people is 10 mg about an hour before sexual activity. The dosage can be increased or decreased up to a maximum of 20 mg depending on the effectiveness and presence of side effects in your body.Vardenafil should not be taken more than once per day as advised by the doctor. Also if you are over 65 years of age, your doctor may start with a starting dose of 5 mg.
Missed dose
Vardenafil is used only as needed, so it is not likely to be on your dosing schedule. Even then, if you miss a dose of vardenafil, take it as soon as you remember. Never exceed the dosage. If it is time for the next dose, skip the previous dose.
Overdose
If you overdose on Vardenafil, tell your doctor or go to the nearest hospital as soon as possible.
Mechanism of action
Vardenafil helps inhibit the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for the degradation of cGMP in the corpus cavernosum that surrounds the penis. Penile erection during sexual arousal is caused by increased penile blood flow, resulting in relaxation of the penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide from nerve terminals and endothelial cells, which stimulate the synthesis of cGMP in smooth muscle cells. Cyclic GMP relaxes smooth muscle and simultaneously increases blood flow to the corpus cavernosum. Inhibition of phosphodiesterase type 5 by vardenafil enhances erectile function by increasing the amount of cGMP.
Adverse side effects
About 40 percent of people using vardenafil experience side effects that are usually mild when taking PDE5 inhibitors. Vardenafil and other PDE5 inhibitors may rarely cause priapism and a painful erection that lasts 6 hours or more. If your erection lasts for more than 4 hours, you need to seek medical help as soon as possible to avoid this permanent damage to your penis.The most common side effects from vardenafil include the following:● Dizziness● Flushing● Headache● Mild low blood pressure● Runny or stuffy nose● IndigestionSome other possible side effects of vardenafil may include the following:● Allergic reaction● Amnesia● Back pain● Bone pain● Pain in chest● Deafness● Heart palpitation● High levels of creatinine kinase● Irregular heartbeat● Muscle pain● QT prolongation● Severe low blood pressure● Tinnitus● Vision loss
Warning and precautions
If there is any disease, injury, or deformity in the penis.
If there is heart disease or blood vessel disease, then use the medicine after telling the doctor.
If there is any disease of the eye which is causing loss of vision.
If you have problems with low blood pressure or angina.
If there is a problem with the way the liver works or the way the kidneys work.
If you have ever had a stroke or heart attack before.
If there is a condition that causes bleeding, such as a stomach ulcer, etc.
If you have sickle cell disease or have ever had bone marrow cancer or leukemia.
You are using any other drugs, including all medicines you are taking that are available to buy without a prescription, as well as herbal and complementary medicines, and recreational drugs.
Have had an allergic reaction to a medicine or are allergic to any of the ingredients in vardenafil.
Who should not take it?
● You should not use vardenafil if you are allergic to it or any of its ingredients, or if you are taking other medicines to treat pulmonary arterial hypertension.● Vardenafil is not for men under the age of 18.● Vardenafil should not be taken if you also use nitrate medicine for chest pain or heart problems. Such as nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also included in some recreational drugs such as amyl nitrate or nitrite. Taking vardenafil along with nitrate medicine may cause a sudden and severe decrease in blood pressure.● If there is a problem of eye disorder such as retinitis pigmentosa, then tell the doctor before taking it.
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FAQs
Is Vardenafil Right for Treatment?Vardenafil is more potent and more selective than Sildenafiland performs its action by inhibiting phosphodiesterase-5. Vardenafil is as effective as sildenafil for treating erectile dysfunction.How much vardenafil do I need to take?Vardenafil should be taken in the recommended dosage of 10 mg as needed approximately 25 to 60 minutes before sexual activity. Depending on your body's efficacy and tolerability the dosage may be increased up to 20 mg and decreased to 5 mg.
Vardenafil Alternatives
Tadalafil (Cialis)
Cialis is an oral tablet that starts working about half an hour after taking it. It can improve your erectile function for up to 36 hours. Its initial dosage is 10 mg, but it can be increased or decreased as needed.
Vardenafil (Levitra)
Levitra should be taken about an hour before sexual activity and the starting dose is usually 10 mg. It should not be taken more than once a day and its oral tablets can be taken with food and also on an empty stomach.
Vardenafil (Staxyn)
Staxyn differs from other ED medications because this tablet is placed on your tongue and allowed to dissolve. This tablet is to be taken about an hour before sexual activity and the tablet should not be crushed or split.
Avanafil (Stendra)
Stendra is available in 50, 100, and 200-mg tablets. It should also be taken about 15 to 30 minutes before sexual activity, but not more than once a day.
Conclusion
We can also call erectile dysfunction impotence which means not being able to get or maintain a proper erection. There can be many reasons for this, the most common being narrowing of the arteries that carry blood to the penis. Vardenafil works by blocking the action of a chemical in your body called phosphodiesterase type-5. Vardenafil is rated 3.4 out of 5 by people and has shown great results as it helps to dilate blood vessels and also improves blood flow to the penis after sexual stimulation.
